Effectiveness of the use of a plant immunostimulator for feline bordetelliosis

A.M. Gontar; R.V Severyn; Ya.V. Hlushchenko; P.O. Zaika; S.I. Symonenko; O.V. Mazaniy; O.V. Nikiforova; B.S. Severyn

doi:10.31073/onehealthjournal2025-I-04

Authors

A.M. Gontar State Biotechnological University, Kharkiv, Ukraine https://orcid.org/0000-0001-7148-5226
R.V Severyn State Biotechnological University, Kharkiv, Ukraine https://orcid.org/0000-0003-2217-8582
Ya.V. Hlushchenko State Biotechnological University, Kharkiv, Ukraine https://orcid.org/0009-0000-7483-9464
P.O. Zaika State Biotechnological University, Kharkiv, Ukraine https://orcid.org/0000-0003-0321-4795
S.I. Symonenko State Biotechnological University, Kharkiv, Ukraine https://orcid.org/0000-0002-7046-2943
O.V. Mazaniy State Biotechnological University, Kharkiv, Ukraine https://orcid.org/0000-0002-4442-4011
O.V. Nikiforova State Biotechnological University, Kharkiv, Ukraine https://orcid.org/0000-0001-5586-5886
B.S. Severyn National Scientific Center "Institute of Experimental and Clinical Veterinary Medicine", Kharkiv, Ukraine https://orcid.org/0009-0008-3285-7531

DOI:

https://doi.org/10.31073/onehealthjournal2025-I-04

Keywords:

cats, respiratory infections, treatment, herbal preparations, herbal immunomodulators

Abstract

In veterinary practice, veterinary specialists solve the important problem of the occurrence and development of immunodeficiency during respiratory infectious pathology in cats with the help of biologically active additives, probiotics, enzymes, immunostimulators and vitamins. Interferons are one of the most popular in use from the list of endogenous immunomodulators. But often the disadvantage of purely immunomodulatory drugs is their difficult transfer and the presence of a negative effect on the body of domestic animals. Therefore, an alternative to interferons in order to increase the immune resistance of the body and improve the well-being of cats is the search, development and use of preparations based on plant raw materials. The article presents the results of the study of the effectiveness of the herbal immunomodulator in comparison with the interferon drug "Anfluron", which was used in two complex treatment schemes for cats suffering from Bodetheliosis infection. To increase the immune resistance of cats for bordeteliosis, an aqueous solution of a medicinal composition based on the Rhodiola rosea root, Oplopanax root, Rozae fruits, Urtica dioica, Crataegus fruits, Hypericum perforatum fruits was used in an effective ratio of 1:1:1:0.8:0.8:0.5. As a result of the use of the specified herbal preparation, a positive trend in the reduction of the manifestation of clinical signs in sick cats was established from the 6th day of use with a direct correlation of the decrease in the manifestation of clinical signs in sick animals treated with a classic interferon drug. As a result of the application of complex therapeutic regimens using various immunomodulatory drugs, a significant alignment of hematological indicators to the physiological norm was noted on the 10th and 14th day of treatment in animals of both study groups. The results obtained in the comparative aspect showed that the proposed herbal preparation has an immunostimulating effect, improves the general condition and can be used in the complex treatment of cats with bordetelliosis.

References

Cattelan N., Dubey P., Arnal L., Yantorno O. M., Deora R. (2015). Bordetellabiofilms: a lifestyle leading to persistent infections. Pathogens and Disease, 74 (1), 108-112. https://doi.org/10.1093/femspd/ftv108.

Cai Y, Fukushi H, Koyasu S, Kuroda E, Yamaguchi T, Hirai K. (2002). An etiological investigation of domestic cats with conjunctivitis and upper respiratory tract disease in Japan. Journal of Veterinary Medical Science, 64, 215-219. https://doi: 10.1292/jvms.64.215.

Dawson S., Jones D., McCracken C. M., Gaskell R. M., Hart C. A., Gaskell C. (2000). Bordetella bronchiseptica infection in cats following contact with infected dogs. Veterinary Record, 146 (2), 46-48. https://doi.org/ 10.1136/vr.146.2.46.

Dmytryshyn O., Stefanyk V. (2019). Influence of some etiological factors on development of gynecological pathology and infertility of cats. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 21 (94), 66-73. https://doi.org/10.32718/nvlvet9412

Egberink H., Addie D, Belak S., Boucraut-Baralon C., Frymus T. et al. (2009). Bordetella bronchiseptica infection in cat ABCD guidelines on prevention and management. Journalof Feline Medicine and Surgery,11, 610-614. https://doi.org/10.1016/j.jfms.2009.05.010

Helps C.R., Lait P., Damhuis A., Bjornehammar U., Bolta D., Brovida C., Chabanne L., Egberink H., Ferrand G., Fontbonne A., Pennisi M.G., Gruffydd-Jones T., Gunn-Moore D., Hartmann K., Lutz H., Malandain E., Mostl K., Stengel C., Harbour D.A., & Graat E.A. (2005). Factors associated with upper respiratory tract disease caused by feline herpesvirus, feline calicivirus, Chlamydophila felis and Bordetella bronchiseptica in cats: experience from 218 European catteries. Veterinary Record, 156(21), 669-73. https://doi.org/10.1136/vr.156.21.669

Hlushchenko Y., Hontar A., Severyn R., Symonenko S., & Shtager H. (2024). Effectiveness comparison of treatment of feline associated Bordetella bronchiseptica infection with the immunostimulants. One Health Journal, 2(IV), 13-19. https://doi.org/10.31073/onehealthjournal2024-IV-02

Kadlec K., Schwarz S. (2018). Antimicrobial Resistance in Bordetella bronchiseptica. Antimicrobial Resistance in Bacteria from Livestock and Companion Animals. Washington, DC, USA, 365-375. https://doi.org/10.1128/ 9781555819804.ch16.

Moore J. E., Rendall J. C., Millar B. C. (2022). A doggy tale: Risk of zoonotic infection with Bordetella bronchiseptica for cystic fibrosis (CF) patients from live licenced bacterial veterinary vaccines for cats and dogs. Journal of Clinical Pharmacy and Therapeutics, 47 (2, 139-145. https://doi.org/10.1111/jcpt.13492.

Moore J. E., Rendall J. C., Millar B. C. (2021). Does Bordetella pertussis vaccine offer any cross-protection against Bordetella bronchiseptica? Implications for pet owners with cystic fibrosis. Journal of Clinical Pharmacy and Therapeutics, 46 (5), 1194-1198. https://doi.org/10.1111/jcpt.13350.

Molyneux J.M., Guilford W.G., Hunter J.E., Gwozdz M., Fenwick S.G., Jones B.R. (2000). Prevalence of Bordetella bronchiseptica in cats attended by a veterinary practice in the Manawatu region. New Zealand Veterinary Journal, 48(3), 82-84. https://doi.org/10.1080/00480169.2000.36165

Redelman-Sidi G., Grommes C., Papanicolaou G. (2011). Kittentransmitted Bordetella bronchiseptica infection in a patient receiving temozolomide for glioblastoma. Journal of Neuro-Oncology, 102, 335-339. https://doi.org/10.1007/s11060-010-0322-6

Register K. B., Sukumar N., Palavecino E. L., Rubin B. K., Deora R. (2012). Bordetella bronchiseptica in a Paediatric Cystic Fibrosis Patient: Possible Transmission from a Household Cat. Zoonoses and Public Health, 59, 246-250. https://doi.org/10.1111/j.1863-2378.2011.01446.x

Walter J, Foley P, Yason C, Vanderstichel R, Muckle A. (2020). Prevalence of feline herpesvirus-1, feline calicivirus, Chlamydia felis, and Bordetella bronchiseptica in a population of shelter cats on Prince Edward Island. Canadian Journal of Veterenary Research, 84(3), 181-188. https://pubmed.ncbi.nlm.nih.gov/32801452/.

Effectiveness of the use of a plant immunostimulator for feline bordetelliosis

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