Approaches to epidemiologic surveillance, diagnosis and prevention of West Nile fever in the Kyiv region
DOI:
https://doi.org/10.31073/onehealthjournal2025-III-01Keywords:
West Nile fever, West Nile virus, surveillance, laboratory diagnosis, preventionAbstract
West Nile virus was first identified in Uganda in 1937 and remains a significant global threat to public health today. This virus is able to adapt to different ecosystems and spread geographically, especially in temperate climate areas of Europe and North America. Currently, cases of West Nile fever are reported in the United States, southern Canada, Mexico, Central and South America and the Caribbean, as well as in Africa, the Middle East, southern Europe, India and Indonesia, etc.
West Nile fever has become more relevant in Ukraine, including in the Kyiv region in the last 10 years. According to data from the State Institution "Public Health Center of the Ministry of Health of Ukraine", 99 cases of West Nile fever were registered in Ukraine in 2024, 43 of them among residents of the Kyiv region.
The manifestations of the disease vary in severity from mild and asymptomatic forms to fever clinic symptoms and central nervous system damage. However, there is no specific treatment for West Nile fever. Timely detection of West Nile virus disease cases requires improved laboratory diagnostics, national standards, and the development of an appropriate system of surveillance for West Nile fever at the national level.
The authors present in this manuscript the results of the analysis of other countries' experience, the presence of a surveillance system in Ukraine, approaches to the laboratory diagnosis of West Nile fever, vectors control of West Nile virus on the example of the Kyiv region.
References
Colpitts T. M., Conway M. J., Montgomery R. R., Fikrig E. (2012). West Nile Virus: Biology, Transmission, and Human Infection. Clin Microbiol Rev. 2012 Oct; 25(4):635-648. DOI: 10.1128/CMR.00045-12.
Cvjetković I. H., Radovanov J., Kovačević G., Turkulov V., Patić A. (2023). Diagnostic value of urine qRT-PCR for the diagnosis of West Nile virus neuroinvasive disease. Diagnostic Microbiology and Infectious Disease. Volume 107, Issue 1, September 2023, 115920 https://doi.org/10.1016/j.diagmicrobio.2023.115920.
Gdoura M., Fares W., Bougatef S., Inoubli A., Touzi H., Hogga N., Dhifallah I. B., Hannachi N., Argoubi A., Kacem S., Karray H., Alaya N. B., Triki H. (2022). The value of West Nile virus RNA detection by real-time RT-PCR in urine samples from patients with neuroinvasive forms / Archives of Microbiology, 2022 Apr 3;204(5):238. DOI: 10.1007/s00203-022-02829-6.
Heymann D. L. (editor) (2022). Control of Communicable Diseases: Manual 21st Edition. American Public Health Association, 2022. - P. 703-706.
Hubálek Z., Halouzka J. (1999). West Nile fever a reemerging mosquito-borne viral disease in Europe. Emerging Infectious Diseases. Sep-Oct; Volume 5, Number 5-October 1999:643-650. DOI: 10.3201/eid0505.990505.
Kemmerly S. A. (2003). Diagnosis and Treatment of West Nile Infections. Ochsner J. 2003 Summer-Autumn; 5(3):16-17. https://pmc.ncbi.nlm.nih.gov/articles/PMC3111824/#:~:text=The%20most%20common%20diagnostic%20method,disease%20(communication%20from%20CDC).
Klingelhöfera D., Brauna M., Kramera I. M., Reussa F., Müller R., Groneberga D. A., Brüggmann D. (2023). A virus becomes a global concern: research activities on West-Nile virus. Emerging Microbes & Infections, 2023, VOL. 12, 2256424 (12 pages), https://doi.org/10.1080/22221751.2023.2256424.
Linthout C., Martins A. D., de Wit M., Delecroix C., Abbo S. R., Pijlman G. P., Koenraadt C. J. M. (2024). The potential role of the Asian bush mosquito Aedes japonicus as a spillover vector for West Nile virus in the Netherlands. Parasites & Vectors volume 17, Article number: 262 (2024). https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-024-06279-5.
Orshan L., Bin H., Schnur H., Kaufman A., Valinsky A., Shulman L., Weiss L., Mendelson E., Pener H. (2008). Mosquito Vectors of West Nile Fever in Israel. Journal of Medical Entomology, Vol. 45, no. 5, 2008. P. 939-947.
Petersen L. R. (2019). Epidemiology of West Nile Virus in the United States: Implications for Arbovirology and Public Health. Journal of Medical Entomology, Volume 56, Issue 6, November 2019, P. 1456-1462, https://doi.org/10.1093/jme/tjz085.
Rochlin I, Faraji A, Healy K, et al. (2019). West Nile virus mosquito vectors in North America. J Med Entomol. 2019 Oct 28; 56(6):1475-1490. DOI:10.
Rothman S. E., Jones J. A.LaDeau S. L., Leisnham P. T. (2021). .Higher West Nile Virus Infection in Aedes albopictus (Diptera: Culicidae) and Culex (Diptera: Culicidae) Mosquitoes From Lower Income Neighborhoods in Urban Baltimore. MD. J Med Entomol. 2021 May 15;58(3):1424-1428. DOI: 10.1093/jme/tjaa262.
Singha P, Khatib M. N., Ballal S., Kaur M., Nathiya D., Sharma S., Siva Prasad G. V., Sinha A., Gaidhane A. M., Mohapatra P., Varma A., Lakhanpal S., Shabil M., Bushi G., Sah S., Serhan H. A. (2025). West Nile Virus in a changing climate: epidemiology, pathology, advances in diagnosis and treatment, vaccine designing and control strategies, emerging public health challenges - a comprehensive review. Emerging Microbes & Infections, Volume 14, 2025 - Issue 1. https://doi.org/10.1080/22221751.2024.2437244.
Soto A., De Coninck L., Devlies A.-S., Van De Wiele C., Rosas A. L. R., Wang L., Matthijnssens J. (2023). Belgian Culex pipiens are competitive vectors for West Nile virus while Culex modestus are competitive vectors for Usutu virus. Journal PLOS, 2023. https://doi.org/10.1371/journal.pntd.0011649.
Tonry J. H., Brown C. B., Cropp C. B, Co J. KG, Bennett S. N, Nerurkar V. R., Kuberski T., Gubler D. J. (2005). West Nile Virus Detection in Urine. Emerging Infectious Disease, 2005 Aug;11(8):1294-1296. DOI: 10.3201/eid1108.050238.
Yuill T. M. (2023). West Nile Virus Infection. MSD Manual, 2023. https://www.msdmanuals.com/home/infections/arboviruses-arenaviruses-filoviruses/west-nile-virus-infection.
Zúñiga M. A. V. (2015). Aspectos clínicos de la infección en seres humanos por el Virus del Nilo Occidental - Clinical Features of West Nile Virus Infection in Humans Rev. Costarricense de Salud Pública, 2015, vol. 24(2): 169-174, https://www.scielo.sa.cr/pdf/rcsp/v24n2/1409-1429-rcsp-24-02-00168.pdf [in Spanish].
Vynograd N.O., Shul U.A., Yurchenko O.O. (2022). Clinical and epidemiological features of West Nile fever in Ukraine at the present stage. - Infectious diseases. 1(107). - 2022. - С. 11-17.
Gerilovych AP, Rodina NS, Gerilovych IO, Okaevych OS (2025). Biosafety in microbiological and biomedical laboratories, 6th edition (translation into Ukrainian), edited by Prof. A.P. Gerilovych - Kharkiv: "Institute of One Health", 2025. 496 p.
Rodyna N.S., Maiboroda V.V., Lipchanchuk V.Ie., Hrynchuk H.M., Mohylna L.O. (2022). Epidemichna sytuatsiia z hariachky Zakhidnoho Nilu v Kyivskii oblasti za period 2017–2021 rr. Zhurnal «Medytsyna nevidkladnykh staniv»: Materialy Naukovo-praktychnoi konferentsii z mizhnarodnoiu uchastiu «Infektsiini khvoroby suchasnosti: etiolohiia, epidemiolohiia, diahnostyka, likuvannia, profilaktyka, biolohichna bezpeka», shcho pryurochena do 135-richchia z dnia narodzhennia akademika L.V. Hromashevskoho. 2022, t. 18, vyp. 6. – s. 93-94. (in Ukrainian).
Shul U.A. (2017). Epidemiolohichni osoblyvosti hariachky Zakhidnoho Nilu ta optymizatsiia systemy epidemiolohichnoho nahliadu na endemichnykh terytoriiakh. Dysertatsiia na zdobuttia naukovoho stupenia kandydata medychnykh nauk. Lviv, 2017, 163 s. (in Ukrainian).
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